en Healthcare setting Healthcare setting پژوهشي Research <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: <i>Stenotrophomonas maltophilia</i> (SMA) is a commensal and an emerging nosocomial pathogen responsible for serious infections, especially in immunocompromised hosts. Its intrinsically multidrug-resistant bacteria to multiple antibiotics. Current study aimed to determine the antibiotic susceptibility patterns of SMA isolates from hospitalized patients in Ilam, Iran.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Materials & Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>This cross-sectional study conducted between September 2022 and February 2023 in Ilam, Iran. Clinical specimens from 85 patients were cultured, and SMA isolates were identified through biochemical testing. Antimicrobial susceptibility testing performed using the disk diffusion method based on CLSI guidelines.<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span></span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Out of 85 samples, 10 (11.76%) isolates were identified as SMA. All isolates were susceptible to Co-trimoxazole (100%), and most were sensitive to Levofloxacin (90%). High resistance rates were observed toward Meropenem, Piperacillin/Tazobactam, Ceftriaxone (100% each), Cefepime (90%), Gentamicin (80%), Ceftazidime (90%), and Amikacin (60%). Our findings indicated the significant multidrug resistance profile of SMA in Ilam.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Continuous surveillance, strict infection control, better antimicrobial stewardship, enhanced research to develop, effective treatment and prevention strategies should be adopted to management the changing resistance profile of SMA.</span></span><br> &nbsp; Stenotrophomonas maltophilia, Antibiotic susceptibility patterns, Multidrug-resistant bacteria 14 19 http://jhsp.medilam.ac.ir/browse.php?a_code=A-10-60-1&slc_lang=en&sid=1 Ali Hematian 1003194753284600267 1003194753284600267 No Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran Mohammad Yazdanmanesh myazdanmaesh.uc@gmail.com 1003194753284600268 1003194753284600268 No Sina khosravi 1003194753284600269 1003194753284600269 Yes Iraj Ahmadi 1003194753284600270 1003194753284600270 No Leila Gheitani 1003194753284600271 1003194753284600271 No Nahid Mahdian 1003194753284600272 1003194753284600272 No Maryam Karimi 1003194753284600273 1003194753284600273 No